Microscale Life Sciences Center - An NIH Center of Excellence in Genomic Science (CEGS)

CEGS-Funded Publications

  1. Zhu, H., Tian, Y., Bhushan, S., Su, F. and Meldrum, D. R. (2012) High throughput micropatterning of optical oxygen sensor for single cell analysis. IEEE Sensors Journal, 12, 1668-1672, 10.1109/JSEN.2011.2176930.
    http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6086560&isnumber=6189422
  2. Lu, H., Su, F., Mei, Q., Tian, Y., Tian, W., Johnson, R. H. and Meldrum, D. R. (2012) Using fluorine-containing amphiphilic random copolymers to manipulate the quantum yields of aggregation-induced emission fluorophores in aqueous solutions and the use of these polymers for fluorescent bioimaging. Journal of Materials Chemistry, 22, 9890, 10.1039/c2jm30258f.
    http://xlink.rsc.org/?DOI=c2jm30258f
  3. Zhou, X., Su, F., Lu, H., Senechal-Willis, P., Tian, Y., Johnson, R. H. and Meldrum, D. R. (2012) An FRET-based ratiometric chemosensor for in vitro cellular fluorescence analyses of pH. Biomaterials, 33, 171-80, 10.1016/j.biomaterials.2011.09.053.
    http://www.ncbi.nlm.nih.gov/pubmed/21982292
  4. Duncombe, T. A., Erdem, E. Y., Shastry, A., Baskaran, R. and Böhringer, K. F. (2012) Controlling liquid drops with texture ratchets. Advanced Materials (Deerfield Beach, Fla.), 24, 1545-50, 10.1002/adma.201104446.
    http://www.ncbi.nlm.nih.gov/pubmed/22331660
  5. Lu, H., Su, F., Mei, Q., Zhou, X., Tian, Y., Tian, W., Johnson, R. H. and Meldrum, D. R. (2012) A series of poly[N-(2-hydroxypropyl)methacrylamide] copolymers with anthracene-derived fluorophores showing aggregation-induced emission properties for bioimaging. Journal of Polymer Science Part A, 50, 890-899, 10.1002/pola.25841. (doi:10.1002/pola.25841)
    http://www.ncbi.nlm.nih.gov/pubmed/22287826
  6. Torres-García, W., Ashili, S., Kelbauskas, L., Johnson, R. H., Zhang, W., Runger, G. C. and Meldrum, D. R. (2012) A statistical framework for multiparameter analysis at the single-cell level. Molecular BioSystems, 8, 804-17, 10.1039/c2mb05429a.
    http://www.ncbi.nlm.nih.gov/pubmed/22222464 (doi:10.1039/c2mb05429a)
  7. Kelbauskas, L., Ashili, S. P., Houkal, J., Smith, D., Mohammadreza, A., Lee, K. B., Forrester, J., Kumar, A., Anis, Y. H., Paulson, T. G., Youngbull, C.A., Tian, Y., Holl, M.R., Johnson, R.H. and Meldrum, D.R. (2012) Method for physiologic phenotype characterization at the single-cell level in non-interacting and interacting cells. Journal of Biomedical Optics, 17, 037008, 10.1117/1.JBO.17.3.037008.
    http://www.ncbi.nlm.nih.gov/pubmed/22502580
  8. Su, F., Alam, R., Mei, Q., Tian, Y., Youngbull, C., Johnson, R. H. and Meldrum, D. R. (2012) Nanostructured oxygen sensor--using micelles to incorporate a hydrophobic platinum porphyrin. PloS One, 7, e33390, 10.1371/journal.pone.0033390.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3310867&tool=pmcentrez&rendertype=abstract
  9. Gao, W., Zhang, W. and Meldrum, D. R. (2011) RT-qPCR based quantitative analysis of gene expression in single bacterial cells. Journal of Microbiological Methods, 85, 221-7, 10.1016/j.mimet.2011.03.008.
    http://www.ncbi.nlm.nih.gov/pubmed/21440012
  10. Zhou, X., Su, F., Gao, W., Tian, Y., Youngbull, C., Johnson, R. H. and Meldrum, D. R. (2011) Triazacryptand-based fluorescent sensors for extracellular and intracellular K+ sensing. Biomaterials, 32, 8574-83, 10.1016/j.biomaterials.2011.07.081.
    http://www.ncbi.nlm.nih.gov/pubmed/21855134
  11. Lu, H., Jin, Y., Tian, Y., Zhang, W., Holl, M. R. and Meldrum, D. R. (2011) New ratiometric optical oxygen and pH dual sensors with three emission colors for measuring photosynthetic activity in cyanobacteria. Journal of Materials Chemistry, 21, 19293, 10.1039/c1jm13754a.
    http://xlink.rsc.org/?DOI=c1jm13754a
  12. Zhou, X., Su, F., Tian, Y., Johnson, R. H. and Meldrum, D. R. (2011) Platinum (II) porphyrin-containing thermoresponsive poly(N-isopropylacrylamide) copolymer as fluorescence dual oxygen and temperature sensor. Sensors and Actuators B, 159, 135-141, 10.1016/j.snb.2011.06.061.
    http://www.ncbi.nlm.nih.gov/pubmed/21927540
  13. Yao, H., Shum, A. J., Cowan, M., Lähdesmäki, I. and Parviz, B. A.(2011) A contact lens with embedded sensor for monitoring tear glucose level. Biosensors and Bioelectronics, 26, 3290-6, 10.1016/j.bios.2010.12.042.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3043144&tool=pmcentrez&rendertype=abstract
  14. Stewart, M. K., Cummings, L. A., Johnson, M. L., Berezow, A. B. and Cookson, B. T. (2011) Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response. Proceedings of the National Academy of Sciences of the United States of America, 108, 20742-7, 10.1073/pnas.1108963108/-/DCSupplemental.www.pnas.org/cgi/doi/10.1073/pnas.1108963108.
    http://www.pnas.org/content/108/51/20742.short
  15. Bergsbaken, T., Fink, S. L., den Hartigh, A. B., Loomis, W. P. and Cookson, B. T. (2011) Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation. Journal of Immunology (Baltimore, Md. : 1950), 187, 2748-54, 10.4049/jimmunol.1100477.
    http://www.ncbi.nlm.nih.gov/pubmed/21804020
  16. Torres-García, W., Brown, S. D., Johnson, R. H., Zhang, W., Runger, G. C. and Meldrum, D. R. (2011) Integrative analysis of transcriptomic and proteomic data of Shewanella oneidensis: missing value imputation using temporal datasets. Molecular BioSystems, 7, 1093-104, 10.1039/c0mb00260g.
    http://www.ncbi.nlm.nih.gov/pubmed/21212895
  17. Ramsay, L. M., Cermak, N., Dada, O. O. and Dovichi, N. J. (2011) Capillary isoelectric focusing with pH 9.7 cathode for the analysis of gastric biopsies. Analytical and Bioanalytical Chemistry, 400, 2025-30, 10.1007/s00216-011-4926-2.
    http://www.ncbi.nlm.nih.gov/pubmed/21461616
  18. Zeng, J., Wang, J., Gao, W., Mohammadreza, A., Kelbauskas, L., Zhang, W., Johnson, R. H. and Meldrum, D. R. (2011) Quantitative single-cell gene expression measurements of multiple genes in response to hypoxia treatment. Analytical and Bioanalytical Chemistry, 401, 3-13, 10.1007/s00216-011-5084-2.
    http://www.ncbi.nlm.nih.gov/pubmed/21614642
  19. Anis, Y., Houkal, J., Holl, M., Johnson, R. H. and Meldrum, D. R. (2011) Diaphragm pico-liter pump for single-cell manipulation. Biomedical Microdevices, 13, 651-9, 10.1007/s10544-011-9535-5.
    http://www.ncbi.nlm.nih.gov/pubmed/21494795
  20. Su, F., Alam, R., Mei, Q., Tian, Y. and Meldrum, D. R. (2011) Micelles as delivery vehicles for oligofluorene for bioimaging. PloS One, 6, e24425, 10.1371/journal.pone.0024425.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3167853&tool=pmcentrez&rendertype=abstract
  21. Zhou, X., Su, F., Tian, Y., Youngbull, C., Johnson, R. H. and Meldrum, D. R. (2011) A new highly selective fluorescent K+ sensor. Journal of the American Chemical Society, 133, 18530-3, 10.1021/ja207345s.
    http://www.ncbi.nlm.nih.gov/pubmed/22579421
  22. Anis, Y. H., Holl, M. R. and Meldrum, D. R. (2010) Automated Selection and Placement of Single Cells Using Vision-Based Feedback Control. IEEE Transactions on Automation Science and Engineering, 7, 598-606, 10.1109/TASE.2009.2035709.
    http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=5373841
  23. Etzkorn, J. R., Wu, W. C., Tian, Z., Kim, P., Jang, S. H., Meldrum, D. R., Jen, A. K. Y. and Parviz, B. A. (2010) Using micro-patterned sensors and cell self-assembly for measuring the oxygen consumption rate of single cells. Journal of Micromechanics and Microengineering, 20, 095017, 10.1088/0960-1317/20/9/095017.
    http://stacks.iop.org/0960-1317/20/i=9/a=095017?key=crossref.79f0395621288f5c796d3c807e3cee46
  24. Ray, T., Zhu, H. and Meldrum, D. R. (2010) Deep reactive ion etching of fused silica using a single-coated soft mask layer for bio-analytical applications. Journal of Micromechanics and Microengineering, 20, 097002, 10.1088/0960-1317/20/9/097002.
    http://stacks.iop.org/0960-1317/20/i=9/a=097002?key=crossref.e8842a4338122b30f820785c5077b8be
  25. Tian, Y., Wu, W. C., Chen, C. Y., Jang, S. H., Zhang, M., Strovas, T., Anderson, J., Cookson, B., Li, Y., Meldrum, D., Chen, W.-C. and Jen, A. K.-Y. (2010) Utilization of micelles formed from poly(ethylene glycol)-block-poly(ε-caprolactone) block copolymers as nanocarriers to enable hydrophobic red two-photon absorbing emitters for cells imaging. Journal of Biomedical Materials Research: Part A, 93, 1068-79, 10.1002/jbm.a.32607.
    http://www.ncbi.nlm.nih.gov/pubmed/19753625
  26. Swearingen, K. E., Loomis, W. P., Kehimkar, B., Cookson, B. T. and Dovichi, N. J. (2010) Quantification of green fluorescent protein in cellular supernatant by capillary electrophoresis with laser-induced fluorescence detection for measurement of cell death. Talanta, 81, 948-953, 10.1016/j.talanta.2010.01.041.Quantification.
    http://www.sciencedirect.com/science/article/pii/S003991401000055X
  27. Tian, Y., Shumway, B. R. and Meldrum, D. R. (2010) A new cross-linkable oxygen sensor covalently bonded into poly (2-hydroxyethyl methacrylate)-co-polyacrylamide thin film for dissolved oxygen sensing. Chemistry of Materials, 22, 2069-2078, 10.1021/cm903361y.A.
    http://pubs.acs.org/doi/abs/10.1021/cm903361y
  28. Jia, Y., Hartshorn, C., Hartung, O. and Wangh, L. J. (2010) Heat shock memory in preimplantation mouse embryos. Fertility and Sterility, 93, 2760-2763, 10.1016/j.fertnstert.2010.02.031.Heat.
    http://www.sciencedirect.com/science/article/pii/S0015028210003109
  29. Tian, Y., Wu, W. C., Chen, C. Y., Strovas, T., Li, Y., Jin, Y., Su, F., Meldrum, D. R. and Jen, A. K. Y. (2010) 2, 1, 3-Benzothiadiazole (BTD)-moiety-containing red emitter conjugated amphiphilic poly (ethylene glycol)-block-poly (ε-caprolactone) copolymers for bioimaging. Journal of Materials Chemistry, 20, 1728-1736, 10.1039/b922435c.2.
    http://xlink.rsc.org/?doi=b922435c
  30. Tian, Y., Shumway, B. R., Youngbull, A.C., Li, Y., Jen, A. K. Y., Johnson, R. H. and Meldrum, D. R. (2010) Dually fluorescent sensing of pH and dissolved oxygen using a membrane made from polymerizable sensing monomers. Sensors and Actuators B, 147, 714-722, 10.1016/j.snb.2010.03.029.Dually.
    http://www.sciencedirect.com/science/article/pii/S0925400510002418
  31. Tian, Y., Shumway, B. R., Gao, W., Youngbull, C., Holl, M. R., Johnson, R. H. and Meldrum, D. R. (2010) Influence of matrices on oxygen sensing of three sensing films with chemically conjugated platinum porphyrin probes and preliminary application for monitoring of oxygen consumption of Escherichia coli (E. coli. Sensors and Actuators B, 150, 579-587, 10.1016/j.snb.2010.08.036.Influence.
    http://www.sciencedirect.com/science/article/pii/S0925400510006970
  32. Tian, Y., Su, F., Weber, W. and Nandakumar, V., Shumway, B.R., Jin, Y., Zhou, X., Holl, M.R., Johnson, R.H. and Meldrum, D.R. (2010) A series of naphthalimide derivatives as intra and extracellular pH sensors. Biomaterials, 31, 7411-7422, 10.1016/j.biomaterials.2010.06.023.A.
    http://www.sciencedirect.com/science/article/pii/S0142961210007714
  33. Dickerson, J. A., Ramsay, L. M., Dada, O. O., Cermak, N. and Dovichi, N. J. (2010) Two‐dimensional capillary electrophoresis: Capillary isoelectric focusing and capillary zone electrophoresis with laser‐induced fluorescence detection. Electrophoresis, 31, 2650-2654, 10.1002/elps.201000151.Two-dimensional.
    http://onlinelibrary.wiley.com/doi/10.1002/elps.201000151/full
  34. Swearingen, K. E., Loomis, W. P., Zheng, M., Cookson, B. T. and Dovichi, N. J. (2010) Proteomic profiling of lipopolysaccharide-activated macrophages by isotope coded affinity tagging. Journal of Proteome Research, 9, 2412-2421.
    http://pubs.acs.org/doi/abs/10.1021/pr901124u
  35. Strovas, T. J., McQuaide, S. C., Anderson, J. B., Nandakumar, V., Kalyuzhnaya, M. G., Burgess, L. W., Holl, M. R., Meldrum, D. R. and Lidstrom, M. E. (2010) Direct measurement of oxygen consumption rates from attached and unattached cells in a reversibly sealed, diffusionally isolated sample chamber. Advances in Bioscience and Biotechnology, 01, 398-408, 10.4236/abb.2010.15053.
    http://www.scirp.org/journal/PaperDownload.aspx?DOI=10.4236/abb.2010.15053
  36. Cheng, X., Yegan Erdem, E., Takeuchi, S., Fujita, H., Ratner, B. D. and Böhringer, K. F. (2010) Infrared light induced patterning of proteins on ppNIPAM thermoresponsive thin films: a “protein laser printer.” Lab on a Chip, 10, 1079-85, 10.1039/b920883f.
    http://www.ncbi.nlm.nih.gov/pubmed/20358117
  37. Jin, Y., Tian, Y., Zhang, W., Jang, S. H., Jen, A. K. Y. and Meldrum, D. R. (2010) Tracking bacterial infection of macrophages using a novel red-emission pH sensor. Analytical and Bioanalytical Chemistry, 398, 1375-84, 10.1007/s00216-010-4060-6.
    http://www.ncbi.nlm.nih.gov/pubmed/20721541
  38. Oak, S., Phan, T. H. T., Gilliam, L. K., Hirsch, I. B. and Hampe, C. S. (2010) Animal insulin therapy induces a biased insulin antibody response that persists for years after introduction of human insulin. Acta Diabetologica, 47, 131-5, 10.1007/s00592-009-0135-2.
    http://www.ncbi.nlm.nih.gov/pubmed/19547910
  39. Li, Y., Thompson, H., Hemphill, C., Hong, F., Forrester, J., Johnson, R. H., Zhang, W. and Meldrum, D. R. (2010) An improved one-tube RT-PCR protocol for analyzing single-cell gene expression in individual mammalian cells. Analytical and Bioanalytical Chemistry, 397, 1853-9, 10.1007/s00216-010-3754-0.
    http://www.ncbi.nlm.nih.gov/pubmed/20490471
  40. Torres-García, W., Zhang, W., Runger, G. C., Johnson, R. H. and Meldrum, D. R. (2009) Integrative analysis of transcriptomic and proteomic data of Desulfovibrio vulgaris: a non-linear model to predict abundance of undetected proteins. Bioinformatics (Oxford, England), 25, 1905-14, 10.1093/bioinformatics/btp325.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2712339&tool=pmcentrez&rendertype=abstract
  41. Zhu, H., Holl, M., Ray, T., Bhushan, S. and Meldrum, D. R. (2009) Characterization of deep wet etching of fused silica glass for single cell and optical sensor deposition. Journal of Micromechanics and Microengineering, 19, 065013, 10.1088/0960-1317/19/6/065013.
    http://stacks.iop.org/0960-1317/19/i=6/a=065013?key=crossref.537716b6933374c4d0d54df584a332df
  42. Lin, L. I., Chao, S. H. and Meldrum, D. R. (2009) Practical, microfabrication-free device for single-cell isolation. PloS One, 4, e6710, 10.1371/journal.pone.0006710.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2725298&tool=pmcentrez&rendertype=abstract
  43. Koschwanez, J. H., Carlson, R. H. and Meldrum, D. R. (2009) Thin PDMS films using long spin times or tert-butyl alcohol as a solvent. PloS One, 4, e4572, 10.1371/journal.pone.0004572.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2642993&tool=pmcentrez&rendertype=abstract
  44. Chao, S. H. and Meldrum, D. R. (2009) Spontaneous, oscillatory liquid transport in surface tension-confined microfluidics. Lab on a Chip, 9, 867-9, 10.1039/b819887j.
    http://www.ncbi.nlm.nih.gov/pubmed/19294295
  45. Mastrangeli, M., Abbasi, S., Varel, C., Van Hoof, C., Celis, J. P. and Bohringer, K. F. (2009) Self-assembly from milli-to nanoscales: methods and applications. Journal of Micromechanics and Microengineering, 19, 1-72, 10.1088/0960-1317/19/8/083001.Self-assembly.
    http://iopscience.iop.org/0960-1317/19/8/083001
  46. Etzkorn, J. R., McQuaide, S. C., Anderson, J. B., Meldrum, D. R. and Parviz, B. A. (2009) Forming self-assembled cell arrays and measuring the oxygen consumption rate of a single live cell. Proceedings of Transducers 2009, Denver, CO, USA, June 21-25, 2009, pp. 2374-2377, 10.1109/SENSOR.2009.5285450.FORMING.
    http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=5285450
  47. Bergsbaken, T. and Cookson, B. T. (2009) Innate immune response during Yersinia infection: critical modulation of cell death mechanisms through phagocyte activation. Journal of Leukocyte Biology, 86, 1153-8, 10.1189/jlb.0309146.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2774879&tool=pmcentrez&rendertype=abstract
  48. Strovas, T. J. and Lidstrom, M. E. (2009) Population heterogeneity in Methylobacterium extorquens AM1. Microbiology (Reading, England), 155, 2040-8, 10.1099/mic.0.025890-0.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2763498&tool=pmcentrez&rendertype=abstract
  49. Molter, T. W., McQuaide, S. C., Suchorolski, M. T., Strovas, T. J., Burgess, L. W., Meldrum, D. R. and Lidstrom, M. E. (2009) A microwell array device capable of measuring single-cell oxygen consumption rates. Sensors and Actuators B, 135, 678-686, 10.1016/j.snb.2008.10.036.A.
    http://www.sciencedirect.com/science/article/pii/S0925400508007314
  50. Bergsbaken, T., Fink, S. L. and Cookson, B. T. (2009) Pyroptosis: host cell death and inflammation. Nature Reviews Microbiology, 7, 99-109, 10.1038/nrmicro2070.
    http://www.nature.com/nrmicro/journal/v7/n2/abs/nrmicro2070.html
  51. McGuire, S., Fisher, C., Holl, M. and Meldrum, D. R. (2008) A novel pressure-driven piezodispenser for nanoliter volumes. The Review of Scientific Instruments, 79, 086111/1-3, 10.1063/1.2969658.
    http://www.ncbi.nlm.nih.gov/pubmed/19044392
  52. Molter, T. W., McQuaide, S. C., Holl, M. R., Meldrum, D. R., Dragavon, J. M., Anderson, J. B., Young, A. C., Burgess, L. W. and Lidstrom, M. E. (2008) A new approach for measuring single-cell oxygen consumption rates. Automation Science, 5, 32-42.
    http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=4380292
  53. Dragavon, J., Molter, T., Young, C., Strovas, T., McQuaide, S., Holl, M., Zhang, M., Cookson, B., Jen, A., Lidstrom, M., Meldrum, D. and Burgess, L. (2008) A cellular isolation system for real-time single-cell oxygen consumption monitoring. Journal of the Royal Society Interface, 5, S151-S159, 10.1098/rsif.2008.0106.focus.
    http://rsif.royalsocietypublishing.org/cgi/doi/10.1098/rsif.2008.0106.focus
  54. Fink, S. L., Bergsbaken, T. and Cookson, B. T. (2008) Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 105, 4312-7, 10.1073/pnas.0707370105.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2393760&tool=pmcentrez&rendertype=abstract
  55. Xu, Y., Zhu, H., Wilcox, C. K., van’t Wout, A., Andrus, T., Llewellyn, N., Stamatatos, L., Mullins, J. I., Corey, L. and Zhu, T. (2008) Blood monocytes harbor HIV type 1 strains with diversified phenotypes including macrophage-specific CCR5 virus. Journal of Infectious Diseases, 197, 309-18, 10.1086/524847.
    http://www.ncbi.nlm.nih.gov/pubmed/18173363
  56. Seriburi, P., McGuire, S., Shastry, A., Böhringer, K. F. and Meldrum, D. R. (2008) Measurement of the cell-substrate separation and the projected area of an individual adherent cell using electric cell-substrate impedance sensing. Analytical Chemistry, 80, 3677-83, 10.1021/ac800036c.
    http://www.ncbi.nlm.nih.gov/pubmed/18407621
  57. Boardman, A. K., McQuaide, S. C., Zhu, C., Whitmore, C. D., Lidstrom, M. E. and Dovichi, N. J. (2008) Interface of an array of five capillaries with an array of one-nanoliter wells for high-resolution electrophoretic analysis as an approach to high-throughput chemical cytometry. Analytical Chemistry, 80, 7631-4, 10.1021/ac800890b.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2636696&tool=pmcentrez&rendertype=abstract
  58. Cohen, D., Dickerson, J. A., Whitmore, C. D., Turner, E. H., Palcic, M. M., Hindsgaul, O. and Dovichi, N. J. (2008) Chemical cytometry: fluorescence-based single-cell analysis. Annual Review of Analytical Chemistry (Palo Alto, Calif.), 1, 165-90, 10.1146/annurev.anchem.1.031207.113104.
    http://www.ncbi.nlm.nih.gov/pubmed/20636078
  59. Turner, E. H., Cohen, D., Pugsley, H. R., Gonzalez Gómez, D., Whitmore, C. D., Zhu, C. and Dovichi, N. J. (2008) Chemical cytometry: the chemical analysis of single cells. Analytical and Bioanalytical Chemistry, 390, 223-6, 10.1007/s00216-007-1665-5.
    http://www.ncbi.nlm.nih.gov/pubmed/17955216
  60. Chao, S. H., Holl, M. R., McQuaide, S. C., Ren, T. T. H., Gales, S. A. and Meldrum, D. R. (2007) Phosphorescence lifetime based oxygen micro-sensing using a digital micromirror device. Optics Express, 15, 10681-9.
    http://www.ncbi.nlm.nih.gov/pubmed/19547422
  61. Koschwanez, J. H., Carlson, R. H. and Meldrum, D. R. (2007) Easily fabricated magnetic traps for single-cell applications. The Review of Scientific Instruments, 78, 044301/1-5, 10.1063/1.2722400.
    http://www.ncbi.nlm.nih.gov/pubmed/17477681
  62. Chao, S. H., Carlson, R. and Meldrum, D. R. (2007) Rapid fabrication of microchannels using microscale plasma activated templating (microPLAT) generated water molds. Lab on a Chip, 7, 641-3, 10.1039/b618269k.
    http://www.ncbi.nlm.nih.gov/pubmed/17476386
  63. Young, A. C., Dragavon, J., Strovas, T., Molter, T., Zheng, L., Burgess, L., Jen, A. K. Y., Lidstrom, M. E. and Meldrum, D. R. (2007) Two-photon lithography of platinum-porphyrin oxygen sensors. IEEE Sensors Journal, 7, 931-936, 10.1109/JSEN.2007.896537.
    http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=4162476
  64. Bergsbaken, T. and Cookson, B. T. (2007) Macrophage activation redirects yersinia-infected host cell death from apoptosis to caspase-1-dependent pyroptosis. PLoS Pathogens, 3, e161, 10.1371/journal.ppat.0030161.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2048529&tool=pmcentrez&rendertype=abstract
  65. Strovas, T. J., Sauter, L. M., Guo, X. and Lidstrom, M. E. (2007) Cell-to-cell heterogeneity in growth rate and gene expression in Methylobacterium extorquens AM1. Journal of Bacteriology, 189, 7127-33, 10.1128/JB.00746-07.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2045205&tool=pmcentrez&rendertype=abstract
  66. Sobhani, K., Fink, S. L., Cookson, B. T. and Dovichi, N. J. (2007) Repeatability of chemical cytometry: 2-DE analysis of single RAW 264.7 macrophage cells. Electrophoresis, 28, 2308-13, 10.1002/elps.200700017.
    http://www.ncbi.nlm.nih.gov/pubmed/17557367
  67. Sobhani, K., Michels, D. A. and Dovichi, N. J. (2007) Sheath-flow cuvette for high-sensitivity laser-induced fluorescence detection in capillary electrophoresis. Applied Spectroscopy, 61, 777-779.
    http://www.opticsinfobase.org/abstract.cfm?id=140188
  68. McClure, J., van’t Wout, A. B., Tran, T. and Mittler, J. E. (2007) Granulocyte-monocyte colony-stimulating factor upregulates HIV-1 replication in monocyte-derived macrophages cultured at low density. Journal of Acquired Immune Deficiency Syndromes (1999), 44, 254-61, 10.1097/QAI.0b013e318030f5c5.
    http://www.ncbi.nlm.nih.gov/pubmed/17211283
  69. Fink, S. L. and Cookson, B. T. (2007) Pyroptosis and host cell death responses during Salmonella infection. Cellular Microbiology, 9, 2562-70, 10.1111/j.1462-5822.2007.01036.x.
    http://www.ncbi.nlm.nih.gov/pubmed/17714514
  70. Jang, L. S., Chao, S. H., Holl, M. R. and Meldrum, D. R. (2007) Resonant mode-hopping micromixing. Sensors and Actuators A, 138, 179-186, 10.1016/j.sna.2007.04.052.Resonant.
    http://www.sciencedirect.com/science/article/pii/S0924424707003305
  71. Kraly, J. R., Jones, M. R., Gomez, D. G., Dickerson, J. A., Harwood, M. M., Eggertson, M., Paulson, T. G., Sanchez, C. A., Odze, R., Feng, Z., Reid, B.J. and Dovichi, N.J. (2006) Reproducible two-dimensional capillary electrophoresis analysis of Barrett’s esophagus tissues. Analytical Chemistry, 78, 5977-5986, 10.1021/ac061029.
    http://pubs.acs.org/doi/pdf/10.1021/ac061029%2B
  72. Meldrum, D. R. (2006) Automated systems for genome analyses. Journal of the Robotics Society of Japan, 24, 570-572. 
    https://www.jstage.jst.go.jp/article/jrsj1983/24/5/24_5_570/_pdf
  73. Ngatchou, P. N., Holl, M., Fisher, C. H., Saini, M. S., Dong, J., Ren, T. T. H., Pence, W. H., Cunningham, D. L., Moody, S. E., Donaldson, D. A. and Meldrum, D.R. (2006) A real-time PCR analyzer compatible with high-throughput automated processing of 2-microliter reactions in glass capillaries. IEEE Transactions on Automation Science and Engineering, 3, 141-151, 10.1109/TASE.2006.871479.
    http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=1613914
  74. Hawley, S. D., Chiu, A. and Chizeck, H. J. (2006) Model identification for DNA sequence-structure relationships. Mathematical Biosciences, 204, 119-31, 10.1016/j.mbs.2006.02.003.
    http://www.ncbi.nlm.nih.gov/pubmed/16603205
  75. Strovas, T. J., Dragavon, J. M., Hankins, T. J., Callis, J. B., Burgess, L. W. and Lidstrom, M. E. (2006) Measurement of respiration rates of Methylobacterium extorquens AM1 cultures by use of a phosphorescence-based sensor. Applied and Environmental Microbiology, 72, 1692-1695, 10.1128/AEM.72.2.1692.
    http://aem.asm.org/content/72/2/1692.short
  76. Cummings, L. A., Wilkerson, W. D., Bergsbaken, T. and Cookson, B. T. (2006) In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted. Molecular Microbiology, 61, 795-809, 10.1111/j.1365-2958.2006.05271.x.
    http://www.ncbi.nlm.nih.gov/pubmed/16803592
  77. Vogel, V. (2006) Mechanotransduction involving multimodular proteins: converting force into biochemical signals. Annual Review of Biophysics and Biomolecular Structure, 35, 459-88, 10.1146/annurev.biophys.35.040405.102013.
    http://www.ncbi.nlm.nih.gov/pubmed/16689645
  78. Fink, S. L. and Cookson, B. T. (2006) Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cellular Microbiology, 8, 1812-25, 10.1111/j.1462-5822.2006.00751.x.
    http://www.ncbi.nlm.nih.gov/pubmed/16824040
  79. Lund, J., Mehta, R. and Parviz, B. A. (2006) Label-free direct electronic detection of biomolecules with amorphous silicon nanostructures. Nanomedicine: Nanotechnology, Biology, and Medicine, 2, 230-238.
    http://www.sciencedirect.com/science/article/pii/S1549963406001432
  80. Salk, J. J., Sanchez, J. A., Pierce, K. E., Rice, J. E., Soares, K. C. and Wangh, L. J. (2006) Direct amplification of single-stranded DNA for pyrosequencing using linear-after-the-exponential (LATE)-PCR. Analytical Biochemistry, 353, 124-132.
    http://www.sciencedirect.com/science/article/pii/S000326970600114X
  81. Shastry, A., Case, M. J. and Bohringer, K. F. (2006) Directing droplets using microstructured surfaces. Langmuir, 22, 6161-6167.
    http://pubs.acs.org/doi/abs/10.1021/la0601657
  82. Jang, L. S., Chao, S. H., Holl, M. R. and Meldrum, D. R. (2005) Microfluidic circulatory flows induced by resonant vibration of diaphragms. Sensors and Actuators A: Physical, 122, 141-148, 10.1016/j.sna.2005.03.070.
    http://linkinghub.elsevier.com/retrieve/pii/S0924424705001561
  83. van ’t Wout, A. B. (2005) Gene expression profiling of HIV-1 infection using cDNA microarrays. Methods in Molecular Biology (Clifton, N.J.), 304, 455-9, 10.1385/1-59259-907-9:455.
    http://www.ncbi.nlm.nih.gov/pubmed/16061997
  84. van ’t Wout, A. B., Swain, J., Schindler, M., Rao, U., Pathmajeyan, M. S., Mullins, J. I. and Kirchhoff, F. (2005) Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells. Journal of Virology, 79, 10053-8, 10.1128/JVI.79.15.10053.
    http://jvi.asm.org/content/79/15/10053.short
  85. Koschwanez, J. and Meldrum, D. R. (2004) Picture Perfect. OE Magazine, 4, 28-30.
    http://spie.org/x16151.xml?pf=true&ArticleID=x16151
  86. Chao, S. H., Holl, M. R., Koschwanez, J. H., Carlson, R. H., Jang, L. S. and Meldrum, D. R. (2004) Velocity measurement in microchannels with a laser confocal microscope and particle linear image velocimetry. Microfluidics and Nanofluidics, 1, 155-160, 10.1007/s10404-004-0023-6.
    http://www.springerlink.com/index/10.1007/s10404-004-0023-6
  87. Koschwanez, J., Holl, M., Marquardt, B., Dragavon, J., Burgess, L. and Meldrum, D. (2004) Identification of budding yeast using a fiber-optic imaging bundle. Review of Scientific Instruments, 75, 1363, 10.1063/1.1710702.
    http://link.aip.org/link/RSINAK/v75/i5/p1363/s1&Agg=doi
  88. Fung, T. H., Ball, G. I., McQuaide, S. C., Chao, S. H., Colman-Lerner, A., Holl, M. R. and Meldrum, D. R. (2004) Microprinting of On-Chip Cultures: Patterning of Yeast Cell Microarrays Using Concanavalin-A Adhesion. Advances in Bioengineering, 373-374.
    http://students.washington.edu/thf/grad/IMECE2004-60866.pdf
  89. Hu, S., Michels, D. A., Fazal, M. A., Ratisoontorn, C., Cunningham, M. L. and Dovichi, N. J. (2004) Capillary sieving electrophoresis/micellar electrokinetic capillary chromatography for two-dimensional protein fingerprinting of single mammalian cells. Analytical Chemistry, 76, 4044-9, 10.1021/ac0498314.
    http://www.ncbi.nlm.nih.gov/pubmed/15253641
  90. Lidstrom, M. E. and Meldrum, D. R. (2003) Life-on-a-chip. Nature Reviews Microbiology, 1, 158-64, 10.1038/nrmicro755.
    http://www.ncbi.nlm.nih.gov/pubmed/15035045
  91. Jensen, M. A. and van ’t Wout, A. B. (2003) Predicting HIV-1 coreceptor usage with sequence analysis. AIDS Reviews, 5, 104-12.
    http://www.aidsreviews.com/audita.asp?d=2003_05_2_104-112.pdf&t=D&w=/n.asp&q=any=2003&vol=5&num=2
  92. Thomas, W. E., Trintchina, E., Forero, M., Vogel, V. and Sokurenko, E. V. (2002) Bacterial adhesion to target cells enhanced by shear force. Cell, 109, 913-23.
    http://www.ncbi.nlm.nih.gov/pubmed/12110187